human MTHFD2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MTHFD2.
shADV-215994
Ad-h-MTHFD2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MTHFD2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
NMDMC
Description (Vector)
MTHFD2 encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. MTHFD2 has a pseudogene on chromosome 7.
Gene ID
10797
Gene Name (Vector)
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Gene Symbol
MTHFD2
HGNC ID
HGNC:7434
ORF Size (aa)
1053
ORF Size (bp)
1053 bp
RefSeq ID
NM_006636
RefSeq Synonyms
NM_006636, BC017054, BC015062, BC001548,
Species
human
UniGene ID
Hs.469030
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.