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human MTA1 shRNA silencing Adenovirus

Name 
Ad-h-MTA1-shRNA
Cat No 
shADV-215964
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human MTA1.

shADV-215964
Ad-h-MTA1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MTA1 (metastasis associated 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
metastasis associated gene 1 protein; metastasis-associated protein MTA1
Description (eCommerce)
MTA1 (metastasis-associated protein 1) is a component of the NuRD (nucleosome remodeling and histone deacetylation) complex. MTA1 was identified as a factor differentially expressed in several types of metastatic carcinoma including breast cancer. MTA1 has also been demonstrated to function as a corepressor for ligand-induced estrogen receptor (ER) transactivation.
Description (Vector)
MTA1 encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
9112
Gene Name (eCommerce)
metastasis associated 1
Gene Name (Vector)
metastasis associated 1
Gene Symbol
MTA1
HGNC ID
HGNC:7410
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2148
ORF Size (bp)
2148 bp
Protein Name (eCommerce)
Metastasis-associated protein MTA1
RefSeq ID
NM_004689
RefSeq Synonyms
NM_004689, NM_001203258, BC142941, BC006177,
Research Areas
Cancer,Epigenetic Regulation of Gene Expression,Signal Transduction,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins,Zinc-finger
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
MTA1 (metastasis-associated protein 1) is a component of the NuRD (nucleosome remodeling and histone deacetylation) complex. MTA1 was identified as a factor differentially expressed in several types of metastatic carcinoma including breast cancer. MTA1 has also been demonstrated to function as a corepressor for ligand-induced estrogen receptor (ER) transactivation.
UniGene ID
Hs.525629
UniProt ID (eCommerce)
Q13330

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.