human MMP11 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MMP11.
shADV-215569
Ad-h-MMP11-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MMP11 (matrix metallopeptidase 11). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
SL-3; ST3; STMY3
Description (Vector)
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
Gene ID
4320
Gene Name (Vector)
matrix metallopeptidase 11
Gene Symbol
MMP11
HGNC ID
HGNC:7157
ORF Size (aa)
1467
ORF Size (bp)
1467 bp
RefSeq ID
NM_005940
RefSeq Synonyms
NM_005940, BC057788,
Species
human
UniGene ID
Hs.143751
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.