human MBD1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MBD1.
shADV-215087
Ad-h-MBD1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MBD1 (methyl-CpG binding domain protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CXXC3; PCM1; RFT
Description (Vector)
MBD1 is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Gene ID
4152
Gene Name (Vector)
methyl-CpG binding domain protein 1
Gene Symbol
MBD1
HGNC ID
HGNC:6916
ORF Size (aa)
1650
ORF Size (bp)
1650 bp
RefSeq ID
NM_002384
RefSeq Synonyms
NM_015847, NM_015846, NM_015845, NM_015844, NM_002384, NM_001323954, NM_001323953, NM_001323952, NM_001323951, NM_001323950, NM_001323949, NM_001323947, NM_001323942, NM_001204151, NM_001204143, NM_001204142, NM_001204141, NM_001204140, NM_001204139, NM_001204138, NM_001204137, NM_001204136, BC033242,
Species
human
UniGene ID
Hs.405610
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.