human MAPKAPK5 shRNA silencing Adenovirus

Name 
Ad-h-MAPKAPK5-shRNA
Cat No 
shADV-215002
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human MAPKAPK5.

shADV-215002
Ad-h-MAPKAPK5-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MAPKAPK5 (mitogen-activated protein kinase-activated protein kinase 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAP-K5; MAPKAPK-5; MK5; MK-5; p38-regulated/activated protein kinase; PRAK
Description (eCommerce)
MK5 (MAP kinase-activated protein kinase 5) is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. [taken from NCBI Entrez Gene (GeneID: 8550)].
Description (Vector)
MAPKAPK5 is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.
Gene ID
8550
Gene Name (eCommerce)
mitogen-activated protein kinase-activated protein kinase 5
Gene Name (Vector)
mitogen-activated protein kinase-activated protein kinase 5
Gene Symbol
MAPKAPK5
HGNC ID
HGNC:6889
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1416
ORF Size (bp)
1416 bp
Protein Name (eCommerce)
MAP kinase-activated protein kinase 5
RefSeq ID
NM_003668
RefSeq Synonyms
NM_139078, NM_003668, BC047284, BC041049,
Research Areas
Cancer,EPO Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,MAPK Signaling,Signal Transduction,Translational Control,Tumor Suppressors/Oncoproteins,VEGF Signaling
Research Areas (Faceted)
cancer,cell_biology,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
MK5 (MAP kinase-activated protein kinase 5) is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. [taken from NCBI Entrez Gene (GeneID: 8550)].
UniGene ID
Hs.413901
UniProt ID (eCommerce)
Q8IW41

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.