human MAP4K1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MAP4K1.
shADV-214949
Ad-h-MAP4K1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Hematopoietic progenitor kinase; hematopoietic progenitor kinase 1; HPK1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mitogen-activated protein kinase kinase kinase kinase 1
Description (eCommerce)
HPK1 (hematopoietic progenitor kinase 1) is a serine/threonine kinase specific to hematopoietic cells including progenitor cells. It is related to the yeast STE20 kinase and is involved in many signaling cascades including the MAPK and JNK/SAPK signaling pathway. HPK1 binds many adaptor proteins which link HPK1 to cell surface receptors and direct its downstream signals.
Gene ID
11184
Gene Name (eCommerce)
mitogen-activated protein kinase kinase kinase kinase 1
Gene Name (Vector)
mitogen-activated protein kinase kinase kinase kinase 1
Gene Symbol
MAP4K1
HGNC ID
HGNC:6863
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2499
ORF Size (bp)
2499 bp
Protein Name (eCommerce)
Mitogen-activated protein kinase kinase kinase kinase 1
RefSeq ID
NM_007181
RefSeq Synonyms
NM_007181, NM_001042600, BC152994, BC148359,
Research Areas
B-cell Receptor Signaling,Cancer,EGFR Signaling,HGF Signaling,Immunology,Insulin Signaling,Kinase/Phosphatase,MAPK Signaling,Prostate Cancer,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling
Research Areas (Faceted)
cancer,cell_biology,immunology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
HPK1 (hematopoietic progenitor kinase 1) is a serine/threonine kinase specific to hematopoietic cells including progenitor cells. It is related to the yeast STE20 kinase and is involved in many signaling cascades including the MAPK and JNK/SAPK signaling pathway. HPK1 binds many adaptor proteins which link HPK1 to cell surface receptors and direct its downstream signals.
UniGene ID
Hs.95424
UniProt ID (eCommerce)
Q92918
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.