human MAP4K1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MAP4K1.
shAAV-214949
AAV-h-MAP4K1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Hematopoietic progenitor kinase; hematopoietic progenitor kinase 1; HPK1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mitogen-activated protein kinase kinase kinase kinase 1
Description (eCommerce)
HPK1 (hematopoietic progenitor kinase 1) is a serine/threonine kinase specific to hematopoietic cells including progenitor cells. It is related to the yeast STE20 kinase and is involved in many signaling cascades including the MAPK and JNK/SAPK signaling pathway. HPK1 binds many adaptor proteins which link HPK1 to cell surface receptors and direct its downstream signals.
Gene ID
11184
Gene Name (eCommerce)
mitogen-activated protein kinase kinase kinase kinase 1
Gene Name (Vector)
mitogen-activated protein kinase kinase kinase kinase 1
Gene Symbol
MAP4K1
HGNC ID
HGNC:6863
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2499
ORF Size (bp)
2499 bp
Protein Name (eCommerce)
Mitogen-activated protein kinase kinase kinase kinase 1
RefSeq ID
NM_007181
RefSeq Synonyms
NM_007181, NM_001042600, BC152994, BC148359,
Research Areas
B-cell Receptor Signaling,Cancer,EGFR Signaling,HGF Signaling,Immunology,Insulin Signaling,Kinase/Phosphatase,MAPK Signaling,Prostate Cancer,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling
Research Areas (Faceted)
cancer,cell_biology,immunology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
HPK1 (hematopoietic progenitor kinase 1) is a serine/threonine kinase specific to hematopoietic cells including progenitor cells. It is related to the yeast STE20 kinase and is involved in many signaling cascades including the MAPK and JNK/SAPK signaling pathway. HPK1 binds many adaptor proteins which link HPK1 to cell surface receptors and direct its downstream signals.
UniGene ID
Hs.95424
UniProt ID (eCommerce)
Q92918
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.