human MAP3K7IP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TAB1.
shADV-214939
Ad-h-MAP3K7IP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
3'-Tab1; MAP3K7IP1; mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TAK1-binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1
Description (eCommerce)
TAB1 interacts with and regulates TAK1 (TGF-beta-activated kinase 1). TAK1 is a MAP kinase kinase kinase that regulates MAP kinase activity in TGF-beta-induced signaling pathways. TAB1 has also been shown to interact with and activate MAPK14/p38alpha.
Description (Vector)
TAB1 was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Gene ID
10454
Gene Name (eCommerce)
TGF-beta activated kinase 1 (MAP3K7) binding protein 1
Gene Name (Vector)
TGF-beta activated kinase 1 (MAP3K7) binding protein 1
Gene Symbol
TAB1
HGNC ID
HGNC:18157
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1515
ORF Size (bp)
1515 bp
Protein Name (eCommerce)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
RefSeq ID
NM_006116
RefSeq Synonyms
NM_153497, NM_006116, BC050554,
Research Areas
B-cell Receptor Signaling,Breast Cancer,Cancer,Cardiac Development,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cytokine Signaling,Fc Receptor Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,MAPK Signaling,NF-kB Signaling,Notch Signaling,RANKL-RANK Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,developmental_biology,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
TAB1 interacts with and regulates TAK1 (TGF-beta-activated kinase 1). TAK1 is a MAP kinase kinase kinase that regulates MAP kinase activity in TGF-beta-induced signaling pathways. TAB1 has also been shown to interact with and activate MAPK14/p38alpha.
UniGene ID
Hs.507681
UniProt ID (eCommerce)
Q15750
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.