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human MAP1B shRNA silencing Adenovirus

Name 
Ad-h-MAP1B-shRNA
Cat No 
shADV-214898
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human MAP1B.

shADV-214898
Ad-h-MAP1B-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MAP1B (microtubule associated protein 1B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
FUTSCH; MAP-1B; MAP5; microtubule-associated protein 1B; PPP1R102; protein phosphatase 1, regulatory subunit 102
Description (eCommerce)
MAP1B is one of the founding members of the MAP (microtubule-associated protein) family of proteins involved in microtubule assembly. MAP1B is almost exclusively expressed in the developing brain and is critical for axon formation. MAP1B-null mice exhibit an absence of the corpus collosum and impaired axon development. MAP1B is processed by proteolytic cleavage that leads to the generation of a 300 kDa heavy chain and a 32 kDa LC1 light chain.
Description (Vector)
MAP1B encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system.
Gene ID
4131
Gene Name (eCommerce)
microtubule associated protein 1B
Gene Name (Vector)
microtubule associated protein 1B
Gene Symbol
MAP1B
HGNC ID
HGNC:6836
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
7407
ORF Size (bp)
7407 bp
Protein Name (eCommerce)
Microtubule-associated protein 1B
RefSeq ID
NM_005909
RefSeq Synonyms
NM_005909, NM_001324255, BC172388,
Research Areas
Cytoskeleton,Kinase/Phosphatase,Neurobiology,Neurodevelopment,Synapse,Transport
Research Areas (Faceted)
cell_biology,neurobiology,developmental_biology,signal_transduction
Species
human
Target Sentence
MAP1B is one of the founding members of the MAP (microtubule-associated protein) family of proteins involved in microtubule assembly. MAP1B is almost exclusively expressed in the developing brain and is critical for axon formation. MAP1B-null mice exhibit an absence of the corpus collosum and impaired axon development. MAP1B is processed by proteolytic cleavage that leads to the generation of a 300 kDa heavy chain and a 32 kDa LC1 light chain.
UniGene ID
Hs.335079
UniProt ID (eCommerce)
P46821

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.