human LGMN shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human LGMN.
shADV-213874
Ad-h-LGMN-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human LGMN (legumain). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AEP; LGMN1; PRSC1
Description (Vector)
LGMN encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. LGMN has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.
Gene ID
5641
Gene Name (Vector)
legumain
Gene Symbol
LGMN
HGNC ID
HGNC:9472
ORF Size (aa)
1302
ORF Size (bp)
1302 bp
RefSeq ID
NM_005606
RefSeq Synonyms
NM_005606, NM_001008530, BC003061,
Species
human
UniGene ID
Hs.18069
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.