human KRIT1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human KRIT1.
shADV-213368
Ad-h-KRIT1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human KRIT1 (KRIT1, ankyrin repeat containing). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CAM; CCM1
Description (Vector)
KRIT1 encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.
Gene ID
889
Gene Name (Vector)
KRIT1, ankyrin repeat containing
Gene Symbol
KRIT1
HGNC ID
HGNC:1573
ORF Size (aa)
2211
ORF Size (bp)
2211 bp
RefSeq ID
NM_004912
RefSeq Synonyms
NM_194456, NM_194455, NM_194454, NM_004912, NM_001013406, BC098442, BC094684,
Species
human
UniGene ID
Hs.531987
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.