human KIT shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human KIT.
shADV-213154
Ad-h-KIT-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human KIT (KIT proto-oncogene receptor tyrosine kinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD antigen CD117; CD117; C-Kit; c-Kit protooncogene; mast/stem cell growth factor receptor Kit; MASTC; p145 c-kit; PBT; piebald trait protein; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCFR; soluble KIT variant 1; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Description (eCommerce)
c-Kit is the receptor for stem cell factor (mast cell growth factor). It is a transmembrane receptor with tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of the c-Kit receptor and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P10721].
Description (Vector)
KIT encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
3815
Gene Name (eCommerce)
KIT proto-oncogene receptor tyrosine kinase
Gene Name (Vector)
KIT proto-oncogene receptor tyrosine kinase
Gene Symbol
KIT
HGNC ID
HGNC:6342
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2931
ORF Size (bp)
2931 bp
Protein Name (eCommerce)
Mast/stem cell growth factor receptor Kit
RefSeq ID
NM_000222
RefSeq Synonyms
NM_001093772, NM_000222, BC071593,
Research Areas
Apoptosis,B Cell Receptor Signaling,Cancer,Cardiac Development,Cardiology,Cardiovascular,Cytoskeleton,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Fc Receptor Signaling,FGF Signaling,Gene Expression,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leukemia,MAPK Signaling,Neurobiology,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,SCF-KIT Signaling,Signal Transduction,Spermatogenesis,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,neurobiology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
c-Kit is the receptor for stem cell factor (mast cell growth factor). It is a transmembrane receptor with tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of the c-Kit receptor and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P10721].
UniGene ID
Hs.479754
UniProt ID (eCommerce)
P10721
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.