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human KIF2C shRNA silencing Adenovirus

Name 
Ad-h-KIF2C-shRNA
Cat No 
shADV-213093
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human KIF2C.

shADV-213093
Ad-h-KIF2C-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human KIF2C (kinesin family member 2C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CT139; kinesin-like protein 6; kinesin-like protein KIF2C; KNSL6; MCAK; mitotic centromere-associated kinesin; testis tissue sperm-binding protein Li 68n
Description (eCommerce)
Kinesin activity has been linked to various cellular functions such as vesicle transport, mitotic spindle formation, chromosome segregation, chromosome congression, and cytokinesis. Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments. MCAK (Mitotic Centromere-Associated Kinesin) is the founding member of kinesin-13 proteins. There are 3 independent genes coding for kinesin-13 proteins kif2a, kif2b, and kif2c (MCAK). Instead of functioning as a translocator of microtubules MCAK is a depolymerizer that is primarily responsible for releasing improper microtubule-kinetochore attachments during cell division.
Description (Vector)
KIF2C is a member of kinesin-like protein family. Proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation.
Gene ID
11004
Gene Name (eCommerce)
kinesin family member 2C
Gene Name (Vector)
kinesin family member 2C
Gene Symbol
KIF2C
HGNC ID
HGNC:6393
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2178
ORF Size (bp)
2178 bp
Protein Name (eCommerce)
Kinesin-like protein KIF2C
RefSeq ID
NM_006845
RefSeq Synonyms
NM_006845, NM_001297657, NM_001297656, NM_001297655, BC014924, BC008764,
Research Areas
Antigen Processing and Presentation,Cell Cycle,Cell Division,Cytoskeleton,Immunology,Signal Transduction,Transport
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,immunology,signal_transduction
Species
human
Target Sentence
Kinesin activity has been linked to various cellular functions such as vesicle transport, mitotic spindle formation, chromosome segregation, chromosome congression, and cytokinesis. Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments. MCAK (Mitotic Centromere-Associated Kinesin) is the founding member of kinesin-13 proteins. There are 3 independent genes coding for kinesin-13 proteins kif2a, kif2b, and kif2c (MCAK). Instead of functioning as a translocator of microtubules MCAK is a depolymerizer that is primarily responsible for releasing improper microtubule-kinetochore attachments during cell division.
UniGene ID
Hs.69360
UniProt ID (eCommerce)
Q99661

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.