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mouse KIF2C shRNA silencing AAV

Name 
AAV-m-KIF2C-shRNA
Cat No 
shAAV-262820
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Kif2c.

shAAV-262820
AAV-m-KIF2C-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Kif2c (kinesin family member 2C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
4930402F02Rik; ESTM5; kinesin-like 6; kinesin-like protein KIF2C; Knsl6; MCAK; mitotic centromere-associated kinesin; X83316
Description (eCommerce)
Kinesin activity has been linked to various cellular functions such as vesicle transport, mitotic spindle formation, chromosome segregation, chromosome congression, and cytokinesis. Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments. MCAK (Mitotic Centromere-Associated Kinesin) is the founding member of kinesin-13 proteins. There are 3 independent genes coding for kinesin-13 proteins kif2a, kif2b, and kif2c (MCAK). Instead of functioning as a translocator of microtubules MCAK is a depolymerizer that is primarily responsible for releasing improper microtubule-kinetochore attachments during cell division.
Description (Vector)
In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.
Gene ID
73804
Gene Name (eCommerce)
kinesin family member 2C
Gene Name (Vector)
kinesin family member 2C
Gene Symbol
Kif2c
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
2166
ORF Size (bp)
2166 bp
Protein Name (eCommerce)
Kinesin-like protein KIF2C
RefSeq ID
NM_134471
RefSeq Synonyms
NM_134471, NM_001290662, BC006841,
Research Areas
Antigen Processing and Presentation,Cell Cycle,Cell Division,Cytoskeleton,Immunology,Signal Transduction,Transport
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,immunology,signal_transduction
Species
mouse
Target Sentence
Kinesin activity has been linked to various cellular functions such as vesicle transport, mitotic spindle formation, chromosome segregation, chromosome congression, and cytokinesis. Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments. MCAK (Mitotic Centromere-Associated Kinesin) is the founding member of kinesin-13 proteins. There are 3 independent genes coding for kinesin-13 proteins kif2a, kif2b, and kif2c (MCAK). Instead of functioning as a translocator of microtubules MCAK is a depolymerizer that is primarily responsible for releasing improper microtubule-kinetochore attachments during cell division.
UniGene ID
Mm.247651
UniProt ID (eCommerce)
Q922S8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.