human KIDINS220 shRNA silencing Adenovirus

Name 
Ad-h-KIDINS220-shRNA
Cat No 
shADV-213062
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human KIDINS220.

shADV-213062
Ad-h-KIDINS220-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human KIDINS220 (kinase D interacting substrate 220). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ankyrin repeat-rich membrane-spanning protein; ARMS; kinase D-interacting substrate 220kDa; kinase D-interacting substrate of 220 kDa; SINO
Description (eCommerce)
Ankyrin repeat-rich membrane-spanning protein (ARMS) is also known as Kinase D-interacting substrate of 220 kDa (KIDINS220). ARMS Promotes prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Arms may play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. ARMS may play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. ARMS has also been shown to modulate stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9ULH0].
Gene ID
57498
Gene Name (eCommerce)
kinase D interacting substrate 220
Gene Name (Vector)
kinase D interacting substrate 220
Gene Symbol
KIDINS220
HGNC ID
HGNC:29508
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5019
ORF Size (bp)
5019 bp
Protein Name (eCommerce)
Kinase D-interacting substrate of 220 kDa
RefSeq ID
NM_020738
RefSeq Synonyms
NM_020738, BC130610,
Research Areas
BDNF Signaling,Neurobiology,Neurodevelopment,Neurogenesis,NGF Signaling,Signal Transduction
Research Areas (Faceted)
developmental_biology,neurobiology,signal_transduction
Species
human
Target Sentence
Ankyrin repeat-rich membrane-spanning protein (ARMS) is also known as Kinase D-interacting substrate of 220 kDa (KIDINS220). ARMS Promotes prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Arms may play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. ARMS may play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. ARMS has also been shown to modulate stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9ULH0].
UniGene ID
Hs.9873
UniProt ID (eCommerce)
Q9ULH0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.