human KDM1 shRNA silencing Adenovirus

Name 
Ad-h-KDM1-shRNA
Cat No 
shADV-212833
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human KDM1A.

shADV-212833
Ad-h-KDM1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human KDM1A (lysine demethylase 1A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
amine oxidase (flavin containing) domain 2; AOF2; BHC110; BRAF35-HDAC complex protein BHC110; CPRF; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; flavin-containing amine oxidase domain-containing protein 2; KDM1; LSD1; lysine (K)-specific demethylase 1A; lysine-specific histone demethylase 1; lysine-specific histone demethylase 1A
Description (eCommerce)
BHC110/LSD1 is a histone demethylase and a component of several histone deacetylase complexes. BHC110/LSD1 is able to specifically catalyze the demethylation of Lys4 of histone H3. As part of histone deacetylase complexes BHC110/LSD1 functions as a corepressor of transcription. BHC110/LSD1 has also been demonstrated to interact with the androgen receptor and stimulate androgen-receptor-dependent transcription.
Description (Vector)
KDM1A encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
Gene ID
23028
Gene Name (eCommerce)
lysine demethylase 1A
Gene Name (Vector)
lysine demethylase 1A
Gene Symbol
KDM1A
HGNC ID
HGNC:29079
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2631
ORF Size (bp)
2631 bp
Protein Name (eCommerce)
Lysine-specific histone demethylase 1A
RefSeq ID
NM_015013
RefSeq Synonyms
NM_015013, NM_001009999, BC048134, BC040194,
Research Areas
Apoptosis,Chromatin Remodeling,DNA Damage/Repair,Histone Modification,Neurobiology,Neurodevelopment,Notch Signaling,RNA Binding,Signal Transduction,Transcription Factor/Regulator,Transport
Research Areas (Faceted)
cell_biology,developmental_biology,genetics,transcription_translation,neurobiology,signal_transduction
Species
human
Target Sentence
BHC110/LSD1 is a histone demethylase and a component of several histone deacetylase complexes. BHC110/LSD1 is able to specifically catalyze the demethylation of Lys4 of histone H3. As part of histone deacetylase complexes BHC110/LSD1 functions as a corepressor of transcription. BHC110/LSD1 has also been demonstrated to interact with the androgen receptor and stimulate androgen-receptor-dependent transcription.
UniGene ID
Hs.656420
UniProt ID (eCommerce)
O60341

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.