human IYD shRNA silencing Adenovirus

Name
Ad-h-IYD-shRNA

Cat No
shADV-212566

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human IYD.

shADV-212566

Ad-h-IYD-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human IYD (iodotyrosine deiodinase). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

C6orf71; DEHAL1; IYD-1; TDH4

Description (Vector)

IYD encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants.

Gene ID

389434

Gene Name (Vector)

iodotyrosine deiodinase

Gene Symbol

IYD

HGNC ID

HGNC:21071

ORF Size (aa)

870

ORF Size (bp)

870 bp

RefSeq ID

NM_203395

RefSeq Synonyms

NM_203395, NM_001318495, NM_001164695, NM_001164694, BC056253,

Species

human

UniGene ID

Hs.310225

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.