human ITSN2 shRNA silencing Adenovirus

Name 
Ad-h-ITSN2-shRNA
Cat No 
shADV-212560
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ITSN2.

shADV-212560
Ad-h-ITSN2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ITSN2 (intersectin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
intersectin-2; PRO2015; SH3 domain-containing protein 1B; SH3D1B; SH3P18; SH3P18-like WASP-associated protein; SWA; SWAP
Description (eCommerce)
Intersectin 2 is an adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery and may regulate the formation of clathrin-coated vesicles [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9NZM3].
Description (Vector)
ITSN2 encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined.
Gene ID
50618
Gene Name (eCommerce)
intersectin 2
Gene Name (Vector)
intersectin 2
Gene Symbol
ITSN2
HGNC ID
HGNC:6184
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5010
ORF Size (bp)
5010 bp
Protein Name (eCommerce)
Intersectin-2
RefSeq ID
NM_019595
RefSeq Synonyms
NM_147152, NM_019595, NM_006277, BC146779,
Research Areas
EGFR Signaling,Immunology,Rho Signaling,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
signal_transduction,immunology
Species
human
Target Sentence
Intersectin 2 is an adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery and may regulate the formation of clathrin-coated vesicles [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9NZM3].
UniGene ID
Hs.432562
UniProt ID (eCommerce)
Q9NZM3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.