human IRF1 shRNA silencing Adenovirus

Name
Ad-h-IRF1-shRNA

Cat No
shADV-212399

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human IRF1.

shADV-212399

Ad-h-IRF1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human IRF1 (interferon regulatory factor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

60

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

interferon regulatory factor 1; interferon regulatory factor 1 isoform +I9; interferon regulatory factor 1 isoform d78; interferon regulatory factor 1 isoform d9,10+; interferon regulatory factor 1 isoform delta4; interferon regulatory factor 1 isoform delta7; IRF-1; MAR

Description (eCommerce)

Interferon regulatory factor 1 (IRF1) is a member of the IRF family of transcription factors that plays a critical role in immune cell function and development. In addition to binding upstream regulatory regions of the type I IFN gene, IRF1 also regulates expression of MHC lass I, and plays a role in apoptosis.

Description (Vector)

IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.

Gene ID

3659

Gene Name (eCommerce)

interferon regulatory factor 1

Gene Name (Vector)

interferon regulatory factor 1

Gene Symbol

IRF1

HGNC ID

HGNC:6116

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

978

ORF Size (bp)

978 bp

Protein Name (eCommerce)

Interferon regulatory factor 1

RefSeq ID

NM_002198

RefSeq Synonyms

NM_002198, BC009483,

Research Areas

Autophagy,Cancer,Cell Cycle,IFN Signaling,Immunology,Interleukin Signaling,NF-kB Signaling,Prolactin Signaling,Toll-like Receptor Signaling,Tumor Suppressors/Oncoproteins

Research Areas (Faceted)

cancer,cell_biology,cell_cycle,genetics,immunology,signal_transduction

Species

human

Target Sentence

Interferon regulatory factor 1 (IRF1) is a member of the IRF family of transcription factors that plays a critical role in immune cell function and development. In addition to binding upstream regulatory regions of the type I IFN gene, IRF1 also regulates expression of MHC lass I, and plays a role in apoptosis.

UniGene ID

Hs.436061

UniProt ID (eCommerce)

P10914

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.