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human IQCB1 shRNA silencing Adenovirus

Name 
Ad-h-IQCB1-shRNA
Cat No 
shADV-212359
Availability
5-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human IQCB1.

shADV-212359
Ad-h-IQCB1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human IQCB1 (IQ motif containing B1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
IQ calmodulin-binding motif-containing protein 1; nephrocystin 5; Nephrocystin-5; NPHP5; p53 and DNA damage-regulated IQ motif protein; PIQ; SLSN5
Description (eCommerce)
IQ calmodulin-binding motif-containing protein 1 (IQCB1) is a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. IQCB1 has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. IQCB1 is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5 [taken from NCBI Entrez Gene (Gene ID: 9657)].
Description (Vector)
IQCB1 encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5. Alternative splicing results in multiple transcript variants.
Gene ID
9657
Gene Name (eCommerce)
IQ motif containing B1
Gene Name (Vector)
IQ motif containing B1
Gene Symbol
IQCB1
HGNC ID
HGNC:28949
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1398
ORF Size (bp)
1398 bp
Protein Name (eCommerce)
IQ calmodulin-binding motif-containing protein 1
RefSeq ID
NM_001023571
RefSeq Synonyms
NM_001319107, NM_001023571, NM_001023570, BC005806,
Research Areas
Cytoskeleton
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
IQ calmodulin-binding motif-containing protein 1 (IQCB1) is a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. IQCB1 has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. IQCB1 is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5 [taken from NCBI Entrez Gene (Gene ID: 9657)].
UniGene ID
Hs.604110
UniProt ID (eCommerce)
Q15051

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.