human IPO8 shRNA silencing Adenovirus

Name 
Ad-h-IPO8-shRNA
Cat No 
shADV-212350
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human IPO8.

shADV-212350
Ad-h-IPO8-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human IPO8 (importin 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
imp8; importin-8; RAN binding protein 8; ran-binding protein 8; RANBP8
Description (eCommerce)
Ran-binding protein 8 (RanBP8), also known as importin-8, bears sequence motifs related to the Ran-binding site of the nucleocytoplasmic transport protein, importin-beta (KPNB1). The Ran-GTPase, along with importin-alpha/beta complexes, provides the energy and directionality for the transport of macromolecules between the cytoplasm and nucleus. RanBP8 seems to have functional properties similar to importin-beta.
Description (Vector)
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
10526
Gene Name (eCommerce)
importin 8
Gene Name (Vector)
importin 8
Gene Symbol
IPO8
HGNC ID
HGNC:9853
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3114
ORF Size (bp)
3114 bp
Protein Name (eCommerce)
Importin-8
RefSeq ID
NM_006390
RefSeq Synonyms
NM_006390, NM_001190995, BC167853,
Research Areas
Signal Transduction,Transport
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
Ran-binding protein 8 (RanBP8), also known as importin-8, bears sequence motifs related to the Ran-binding site of the nucleocytoplasmic transport protein, importin-beta (KPNB1). The Ran-GTPase, along with importin-alpha/beta complexes, provides the energy and directionality for the transport of macromolecules between the cytoplasm and nucleus. RanBP8 seems to have functional properties similar to importin-beta.
UniGene ID
Hs.505136
UniProt ID (eCommerce)
O15397

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.