human IFNG shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human IFNG.
shADV-211876
Ad-h-IFNG-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human IFNG (interferon gamma). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IFG;IFI;IFN-gamma;immune interferon;interferon gamma
Description (eCommerce)
IFN-gamma is a soluble cytokine that is a member of the type II interferon class. It is produced by immune cells such as T-cells and NK cells and plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. [taken from NCBI Entrez Gene (Gene ID: 3458)].
Description (Vector)
IFNG encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.
Gene ID
3458
Gene Name (eCommerce)
interferon gamma
Gene Name (Vector)
interferon gamma
Gene Symbol
IFNG
HGNC ID
HGNC:5438
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
501
Protein Name (eCommerce)
Interferon gamma
RefSeq ID
NM_000619
RefSeq Synonyms
NM_000619, BC070256,
Research Areas
Antigen Processing and Presentation,Apoptosis,Autophagy,Cancer,Cardiology,Cardiovascular,Cell Cycle,Complexome,Cytokine Signaling,GPCR Signaling,HIF-1 Signaling,Host-Virus Interactions,IFN Signaling,Immunology,Interleukin Signaling,JAK-STAT Signaling,Neurobiology,Neurodevelopment,Proteasome,Response to Virus,Signal Transduction,T Cell Receptor Signaling,TGF-beta Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
IFN-gamma is a soluble cytokine that is a member of the type II interferon class. It is produced by immune cells such as T-cells and NK cells and plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. [taken from NCBI Entrez Gene (Gene ID: 3458)].
UniGene ID
Hs.856
UniProt ID (eCommerce)
P01579
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.