human HLA-DMA shRNA silencing Adenovirus

Name 
Ad-h-HLA-DMA-shRNA
Cat No 
shADV-211211
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human HLA-DMA.

shADV-211211
Ad-h-HLA-DMA-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human HLA-DMA (major histocompatibility complex, class II, DM alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
D6S222E; DMA; HLADM; RING6
Description (Vector)
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
Gene ID
3108
Gene Name (Vector)
major histocompatibility complex, class II, DM alpha
Gene Symbol
HLA-DMA
HGNC ID
HGNC:4934
ORF Size (aa)
786
ORF Size (bp)
786 bp
RefSeq ID
NM_006120
RefSeq Synonyms
NM_006120, BC026279, BC011447,
Species
human
UniGene ID
Hs.351279

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.