human HIST4H4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human HIST4H4.
shADV-211167
Ad-h-HIST4H4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human HIST4H4 (histone cluster 4 H4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
H4/p; histone 4, H4; histone H4
Description (eCommerce)
Histone H4 is one of four histone proteins that assemble into an octamer to form the nucleosome core and serve to spool and compact DNA into chromatin. Histones are subject to a complex set of post-translational modifications (acetylation, methylation, phosphorylation, ubiquitination, sumoylation, citrullination, and ADP ribosylation) that are important to the regulation of gene transcription, DNA replication, and DNA repair.
Description (Vector)
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element.
Gene ID
121504
Gene Name (eCommerce)
histone cluster 4 H4
Gene Name (Vector)
histone cluster 4 H4
Gene Symbol
HIST4H4
HGNC ID
HGNC:20510
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
312
Protein Name (eCommerce)
Histone H4
RefSeq ID
NM_175054
RefSeq Synonyms
NM_175054, BC111434, BC111093,
Research Areas
Cancer,Cell Cycle,Chromatin Remodeling,Epigenetic Regulation of Gene Expression,Gene Expression,Histone Modification,Host-Virus Interactions,Meiosis,Signal Transduction,Telomeric Maintenance,Viral Carcinogenesis
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,infectious_disease,signal_transduction
Species
human
Target Sentence
Histone H4 is one of four histone proteins that assemble into an octamer to form the nucleosome core and serve to spool and compact DNA into chromatin. Histones are subject to a complex set of post-translational modifications (acetylation, methylation, phosphorylation, ubiquitination, sumoylation, citrullination, and ADP ribosylation) that are important to the regulation of gene transcription, DNA replication, and DNA repair.
UniGene ID
Hs.528055
UniProt ID (eCommerce)
P62805
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.