human HIRA shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human HIRA.
shADV-211046
Ad-h-HIRA-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human HIRA (histone cell cycle regulator). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DGCR1; TUP1; TUPLE1
Description (Vector)
HIRA encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. HIRA plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
Gene ID
7290
Gene Name (Vector)
histone cell cycle regulator
Gene Symbol
HIRA
HGNC ID
HGNC:4916
ORF Size (aa)
3054
ORF Size (bp)
3054 bp
RefSeq ID
NM_003325
RefSeq Synonyms
NM_003325, BC039835,
Species
human
UniGene ID
Hs.474206
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.