human HEXB shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human HEXB.
shADV-210980
Ad-h-HEXB-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human HEXB (hexosaminidase subunit beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ENC-1AS; HEL-248; HEL-S-111
Description (Vector)
Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II).
Gene ID
3074
Gene Name (Vector)
hexosaminidase subunit beta
Gene Symbol
HEXB
HGNC ID
HGNC:4879
ORF Size (aa)
1671
ORF Size (bp)
1671 bp
RefSeq ID
NM_000521
RefSeq Synonyms
NM_001292004, NM_000521, BC017378,
Species
human
UniGene ID
Hs.69293
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.