human HADHA shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human HADHA.
shADV-210761
Ad-h-HADHA-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human HADHA (hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
3-ketoacyl-Coenzyme A (CoA) thiolase, alpha subunit; 3-oxoacyl-CoA thiolase; 78 kDa gastrin-binding protein; ECHA; gastrin-binding protein; GBP; HADH; LCEH; LCHAD; long-chain 2-enoyl-CoA hydratase; Long-chain enoyl-CoA hydratase; long-chain-3-hydroxyacyl-CoA dehydrogenase; mitochondrial trifunctional enzyme, alpha subunit; MTPA; TP-ALPHA; trifunctional enzyme subunit alpha, mitochondrial
Description (eCommerce)
HADHA is the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities[taken from NCBI Entrez Gene (Gene ID: 3030)].
Description (Vector)
HADHA encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation.
Gene ID
3030
Gene Name (eCommerce)
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
Gene Name (Vector)
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
Gene Symbol
HADHA
HGNC ID
HGNC:4801
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2292
ORF Size (bp)
2292 bp
Protein Name (eCommerce)
Trifunctional enzyme subunit alpha, mitochondrial
RefSeq ID
NM_000182
RefSeq Synonyms
NM_000182, BC009235,
Research Areas
Cardiology,Cardiovascular,Metabolism/Metabolic Process,Mitochondrion
Research Areas (Faceted)
cardiovascular,metabolism,cell_biology
Species
human
Target Sentence
HADHA is the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities[taken from NCBI Entrez Gene (Gene ID: 3030)].
UniGene ID
Hs.516032
UniProt ID (eCommerce)
P40939
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.