human GUCY2D shRNA silencing Adenovirus

Cat. No: shADV-210692

Availability: 5-8 weeks

Name: Ad-h-GUCY2D-shRNA

This is an Adenovirus expressing shRNA for silencing of Human GUCY2D.

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Species: Human
Gene Symbol: GUCY2D
Gene Name: guanylate cyclase 2D, retinal
Gene ID: 3000
Gene Synonyms: CORD5; CORD6; CYGD; GUC1A4; GUC2D; LCA; LCA1; RCD2; retGC; RETGC-1; ROS-GC1; ROSGC
ORF Size: 3309 bp
RefSeq#: NM_000180
Gene Description: GUCY2D encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases.
UniGene ID: Hs.592109
HGNC ID: HGNC:4689