human GRM4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human GRM4.
shADV-210551
Ad-h-GRM4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human GRM4 (glutamate metabotropic receptor 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GPRC1D; mGlu4; MGLUR4
Description (Vector)
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.
Gene ID
2914
Gene Name (Vector)
glutamate metabotropic receptor 4
Gene Symbol
GRM4
HGNC ID
HGNC:4596
ORF Size (aa)
2739
ORF Size (bp)
2739 bp
RefSeq ID
NM_000841
RefSeq Synonyms
NM_001282847, NM_001256813, NM_001256812, NM_001256811, NM_001256809, NM_000841, BC130528, BC130526,
Species
human
UniGene ID
Hs.654847
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.