human GRAP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human GRAP.
shADV-210481
Ad-h-GRAP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human GRAP (GRB2-related adaptor protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
GRAP encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.
Gene ID
10750
Gene Name (Vector)
GRB2-related adaptor protein
Gene Symbol
GRAP
HGNC ID
HGNC:4562
ORF Size (aa)
654
ORF Size (bp)
654 bp
RefSeq ID
NM_006613
RefSeq Synonyms
NM_006613, NM_001330148, BC063035, BC035856,
Species
human
UniGene ID
Hs.567416
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.