human GMNN shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human GMNN.
shADV-210048
Ad-h-GMNN-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human GMNN (geminin, DNA replication inhibitor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Gem; geminin; MGORS6
Description (eCommerce)
Geminin has been identified as a protein that inhibits DNA replication during S, G2, and M phases in association with Cdt1 (chromatin licensing and DNA replication factor). Geminin prevents the binding of the MCM complex onto origins of replication, and its abundance is regulated by ubiquitin ligase activity of the APC/C (anaphase-promoting/cyclosome) complex.
Description (Vector)
GMNN encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.
Gene ID
51053
Gene Name (eCommerce)
geminin, DNA replication inhibitor
Gene Name (Vector)
geminin, DNA replication inhibitor
Gene Symbol
GMNN
HGNC ID
HGNC:17493
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
630
ORF Size (bp)
630 bp
Protein Name (eCommerce)
Geminin
RefSeq ID
NM_015895
RefSeq Synonyms
NM_015895, NM_001251991, NM_001251990, NM_001251989, BC005389, BC005185,
Research Areas
Cell Cycle,DNA Replication,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
Geminin has been identified as a protein that inhibits DNA replication during S, G2, and M phases in association with Cdt1 (chromatin licensing and DNA replication factor). Geminin prevents the binding of the MCM complex onto origins of replication, and its abundance is regulated by ubiquitin ligase activity of the APC/C (anaphase-promoting/cyclosome) complex.
UniGene ID
Hs.234896
UniProt ID (eCommerce)
O75496
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.