human GM2A shRNA silencing Adenovirus

Name 
Ad-h-GM2A-shRNA
Cat No 
shADV-210031
Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human GM2A.

shADV-210031
Ad-h-GM2A-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human GM2A (GM2 ganglioside activator). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
GM2-AP; SAP-3
Description (Vector)
GM2A encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants.
Gene ID
2760
Gene Name (Vector)
GM2 ganglioside activator
Gene Symbol
GM2A
HGNC ID
HGNC:4367
ORF Size (aa)
582
RefSeq ID
NM_000405
RefSeq Synonyms
NM_001167607, NM_000405, BC009273,
Species
human
UniGene ID
Hs.483873

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.