human GLDC shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human GLDC.
shADV-209960
Ad-h-GLDC-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human GLDC (glycine decarboxylase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GCE; GCSP; HYGN1
Description (Vector)
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).
Gene ID
2731
Gene Name (Vector)
glycine decarboxylase
Gene Symbol
GLDC
HGNC ID
HGNC:4313
ORF Size (aa)
3063
ORF Size (bp)
3063 bp
RefSeq ID
NM_000170
RefSeq Synonyms
NM_000170, BC111995, BC111993,
Species
human
UniGene ID
Hs.584238
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.