human GDNF shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-209792
Availability:
5-8 weeks
Name:
Ad-h-GDNF-shRNA
This is an Adenovirus expressing shRNA for silencing of Human GDNF.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- GDNF
- Gene Name
- glial cell derived neurotrophic factor
- Gene ID
- 2668
- Gene Synonyms
- ATF; ATF1; ATF2; HFB1-GDNF; HSCR3
- ORF Size
- 636 bp
- RefSeq#
- NM_000514
- Gene Description
- GDNF encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease.
- UniGene ID
- Hs.248114
- HGNC ID
- HGNC:4232
Related Products
Product | Cat No. |
---|---|
AAV-h-GDNF | AAV-209792 |
AAV-m-GDNF | AAV-260022 |
Ad-h-GDNF | ADV-209792 |
Ad-m-GDNF | ADV-260022 |
AAV-h-GDNF-shRNA | shAAV-209792 |
AAV-m-GDNF-shRNA | shAAV-260022 |
Ad-m-GDNF-shRNA | shADV-260022 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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