human GDNF shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human GDNF.
shADV-209792
Ad-h-GDNF-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human GDNF (glial cell derived neurotrophic factor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATF; ATF1; ATF2; HFB1-GDNF; HSCR3
Description (Vector)
GDNF encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease.
Gene ID
2668
Gene Name (Vector)
glial cell derived neurotrophic factor
Gene Symbol
GDNF
HGNC ID
HGNC:4232
ORF Size (aa)
636
ORF Size (bp)
636 bp
RefSeq ID
NM_000514
RefSeq Synonyms
NM_199231, NM_001278098, NM_001190469, NM_001190468, NM_000514, BC128109, BC128108, BC069369, BC069119,
Species
human
UniGene ID
Hs.248114
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.