human GADD45B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human GADD45B.
shADV-209542
Ad-h-GADD45B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human GADD45B (growth arrest and DNA damage inducible beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GADD45BETA; MYD118
Description (Vector)
GADD45B is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.
Gene ID
4616
Gene Name (Vector)
growth arrest and DNA damage inducible beta
Gene Symbol
GADD45B
HGNC ID
HGNC:4096
ORF Size (aa)
483
RefSeq ID
NM_015675
RefSeq Synonyms
NM_015675, BC117469, BC113466,
Species
human
UniGene ID
Hs.110571
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.