human FOXM1 shRNA silencing Adenovirus

Name 
Ad-h-FOXM1-shRNA
Cat No 
shADV-209265
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human FOXM1.

shADV-209265
Ad-h-FOXM1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human FOXM1 (forkhead box M1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
a novel forkhead box M1 isoform FOXM1D; FKHL16; forkhead box protein M1; Forkhead, drosophila, homolog-like 16; forkhead-related protein FKHL16; FOXM1A; FOXM1B; FOXM1C; hepatocyte nuclear factor 3 forkhead homolog 11; HFH11; HFH-11; HNF-3; HNF-3/fork-head homolog 11; INS-1; M-phase phosphoprotein 2; MPHOSPH2; MPM-2 reactive phosphoprotein 2; MPP2; MPP-2; PIG29; transcription factor Trident; TRIDENT; winged-helix factor from INS-1 cells
Description (eCommerce)
FOXM1 belongs to a large family of Forkhead transcription factors that possesses a winged-helix DNA-binding domain called Forkhead box (FOX). It is a transcription factor critical to cell cycle progression via its role in coordinating the G2/M phase transition. FOXM1 is ubiquitously expressed in proliferating cells but is absent in differentiated cells. FOXM1 overexpression has been detected in a variety of tumor types including breast, lung, prostate, and liver cancer, and appears to be involved in tumorigenesis-associated processes such as angiogenesis and metastasis. In light of these findings, FOXM1 has recently become an attractive target for anti-cancer therapy.
Description (Vector)
FOXM1 is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene.
Gene ID
2305
Gene Name (eCommerce)
forkhead box M1
Gene Name (Vector)
forkhead box M1
Gene Symbol
FOXM1
HGNC ID
HGNC:3818
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2292
ORF Size (bp)
2292 bp
Protein Name (eCommerce)
Forkhead box protein M1
RefSeq ID
NM_021953
RefSeq Synonyms
NM_202003, NM_202002, NM_021953, NM_001243089, NM_001243088, BC012863, BC006529, BC006192,
Research Areas
Aging,Cardiovascular,Cell Cycle,DNA Damage/Repair,MAPK Signaling,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cardiovascular,cell_biology,cell_cycle,genetics,transcription_translation,signal_transduction
Species
human
Target Sentence
FOXM1 belongs to a large family of Forkhead transcription factors that possesses a winged-helix DNA-binding domain called Forkhead box (FOX). It is a transcription factor critical to cell cycle progression via its role in coordinating the G2/M phase transition. FOXM1 is ubiquitously expressed in proliferating cells but is absent in differentiated cells. FOXM1 overexpression has been detected in a variety of tumor types including breast, lung, prostate, and liver cancer, and appears to be involved in tumorigenesis-associated processes such as angiogenesis and metastasis. In light of these findings, FOXM1 has recently become an attractive target for anti-cancer therapy.
UniGene ID
Hs.239
UniProt ID (eCommerce)
Q08050

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.