human FMR1 shRNA silencing Adenovirus

Name 
Ad-h-FMR1-shRNA
Cat No 
shADV-209186
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human FMR1.

shADV-209186
Ad-h-FMR1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human FMR1 (fragile X mental retardation 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
FMRP; fragile X mental retardation protein 1; FRAXA; POF; POF1; Protein FMR-1; synaptic functional regulator FMR1
Description (eCommerce)
Fragile X mental retardation protein 1 is the product of the gene FMR1, also known as FMRP. This protein binds RNA and is associated with polysomes. FMRP may also be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1).
Description (Vector)
FMR1 binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
Gene ID
2332
Gene Name (eCommerce)
fragile X mental retardation 1
Gene Name (Vector)
fragile X mental retardation 1
Gene Symbol
FMR1
HGNC ID
HGNC:3775
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1761
ORF Size (bp)
1761 bp
Protein Name (eCommerce)
Fragile X mental retardation protein 1
RefSeq ID
NM_002024
RefSeq Synonyms
NM_002024, NM_001185082, NM_001185081, NM_001185076, NM_001185075, BC086957, BC038998,
Research Areas
mRNA Binding,mRNA transport,Neurobiology,Neurodevelopment,RNA Binding,RNA Transport,Translational Control
Research Areas (Faceted)
genetics,transcription_translation,neurobiology,developmental_biology,genetics,cell_biology
Species
human
Target Sentence
Fragile X mental retardation protein 1 is the product of the gene FMR1, also known as FMRP. This protein binds RNA and is associated with polysomes. FMRP may also be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1).
UniGene ID
Hs.103183
UniProt ID (eCommerce)
Q06787

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.