human FGF23 shRNA silencing Adenovirus

Name
Ad-h-FGF23-shRNA

Cat No
shADV-208967

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human FGF23.

shADV-208967

Ad-h-FGF23-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human FGF23 (fibroblast growth factor 23). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

ADHR; FGFN; HPDR2; HYPF; PHPTC

Description (Vector)

FGF23 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The product of this gene inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets (ADHR), an inherited phosphate wasting disorder. Abnormally high level expression of this gene was found in oncogenic hypophosphatemic osteomalacia (OHO), a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations in this gene have also been shown to cause familial tumoral calcinosis with hyperphosphatemia.

Gene ID

8074

Gene Name (Vector)

fibroblast growth factor 23

Gene Symbol

FGF23

HGNC ID

HGNC:3680

ORF Size (aa)

756

ORF Size (bp)

756 bp

RefSeq ID

NM_020638

RefSeq Synonyms

NM_020638, BC098252, BC098147, BC096713, BC069333,

Species

human

UniGene ID

Hs.287370

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.