human FGD1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human FGD1.
shADV-208932
Ad-h-FGD1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human FGD1 (FYVE, RhoGEF and PH domain containing 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AAS; faciogenital dysplasia 1 protein; FGDY; FYVE, RhoGEF and PH domain-containing protein 1; MRXS16; rho/Rac GEF; rho/Rac guanine nucleotide exchange factor FGD1; ZFYVE3; zinc finger FYVE domain-containing protein 3
Description (eCommerce)
The gene FGD1 encodes for FYVE, RhoGEF and PH domain-containing protein 1. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16 [taken from NCBI Entrez Gene (Gene ID: 2245)].
Description (Vector)
FGD1 encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16.
Gene ID
2245
Gene Name (eCommerce)
FYVE, RhoGEF and PH domain containing 1
Gene Name (Vector)
FYVE, RhoGEF and PH domain containing 1
Gene Symbol
FGD1
HGNC ID
HGNC:3663
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2886
ORF Size (bp)
2886 bp
Protein Name (eCommerce)
FYVE, RhoGEF and PH domain-containing protein 1
RefSeq ID
NM_004463
RefSeq Synonyms
NM_004463, BC034530,
Research Areas
Apoptosis,Cytoskeleton,Golgi Apparatus,GPCR Signaling,Neurobiology,NGF Signaling,Signal Transduction,Zinc-finger
Research Areas (Faceted)
cell_biology,neurobiology,signal_transduction
Species
human
Target Sentence
The gene FGD1 encodes for FYVE, RhoGEF and PH domain-containing protein 1. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16 [taken from NCBI Entrez Gene (Gene ID: 2245)].
UniGene ID
Hs.709201
UniProt ID (eCommerce)
P98174
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.