human FBXW2 shRNA silencing Adenovirus

Name
Ad-h-FBXW2-shRNA

Cat No
shADV-208834

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human FBXW2.

shADV-208834

Ad-h-FBXW2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human FBXW2 (F-box and WD repeat domain containing 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

FBW2; Fwd2; Md6

Description (Vector)

F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.

Gene ID

26190

Gene Name (Vector)

F-box and WD repeat domain containing 2

Gene Symbol

FBXW2

HGNC ID

HGNC:13608

ORF Size (aa)

1365

ORF Size (bp)

1365 bp

RefSeq ID

NM_012164

RefSeq Synonyms

NM_012164, BC110334, BC018738,

Species

human

UniGene ID

Hs.494985

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.