human FAP shRNA silencing Adenovirus

Name 
Ad-h-FAP-shRNA
Cat No 
shADV-208710
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human FAP.

shADV-208710
Ad-h-FAP-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human FAP (fibroblast activation protein alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
170 kDa melanoma membrane-bound gelatinase; dipeptidyl peptidase FAP; DPPIV; FAPA; FAPalpha; Fibroblast activation protein alpha; gelatine degradation protease FAP; integral membrane serine protease; post-proline cleaving enzyme; prolyl endopeptidase FAP; seprase; Serine integral membrane protease; SIMP; surface-expressed protease
Description (eCommerce)
Fibroblast Activation Protein alpha, or FAP, is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. FAP is involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. [taken from NCBI Entrez Gene (Gene ID: 2191)].
Description (Vector)
FAP is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.
Gene ID
2191
Gene Name (eCommerce)
fibroblast activation protein alpha
Gene Name (Vector)
fibroblast activation protein alpha
Gene Symbol
FAP
HGNC ID
HGNC:3590
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2283
ORF Size (bp)
2283 bp
Protein Name (eCommerce)
Prolyl endopeptidase FAP
RefSeq ID
NM_004460
RefSeq Synonyms
NM_004460, NM_001291807, BC026250,
Research Areas
Angiogenesis,Apoptosis,Cell Biology,Cell Cycle
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics
Species
human
Target Sentence
Fibroblast Activation Protein alpha, or FAP, is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. FAP is involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. [taken from NCBI Entrez Gene (Gene ID: 2191)].
UniGene ID
Hs.654370
UniProt ID (eCommerce)
Q12884

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.