human EXOC5 shRNA silencing Adenovirus

Name 
Ad-h-EXOC5-shRNA
Cat No 
shADV-208177
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EXOC5.

shADV-208177
Ad-h-EXOC5-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EXOC5 (exocyst complex component 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
exocyst complex component 5; exocyst complex component Sec10; HSEC10; PRO1912; SEC10; SEC10L1; SEC10-like 1; SEC10P
Description (eCommerce)
EXOC5 is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including EXOC5, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity [taken from NCBI Entrez Gene (Gene ID: 10640)].
Description (Vector)
EXOC5 is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.
Gene ID
10640
Gene Name (eCommerce)
exocyst complex component 5
Gene Name (Vector)
exocyst complex component 5
Gene Symbol
EXOC5
HGNC ID
HGNC:10696
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2127
ORF Size (bp)
2127 bp
Protein Name (eCommerce)
Exocyst complex component 5
RefSeq ID
NM_006544
RefSeq Synonyms
NM_006544, BC041126,
Research Areas
Golgi Apparatus,Insulin Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,signal_transduction
Species
human
Target Sentence
EXOC5 is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including EXOC5, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity [taken from NCBI Entrez Gene (Gene ID: 10640)].
UniGene ID
Hs.715522
UniProt ID (eCommerce)
O00471

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.