human EVPL shRNA silencing Adenovirus

Name 
Ad-h-EVPL-shRNA
Cat No 
shADV-208164
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EVPL.

shADV-208164
Ad-h-EVPL-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EVPL (envoplakin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
210 kDa cornified envelope precursor protein; 210 kDa paraneoplastic pemphigus antigen; envoplakin; EVPK; p210
Description (eCommerce)
Envoplakin is a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. The gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against Envoplakin [taken from NCBI Entrez Gene (Gene ID: 2125)].
Gene ID
2125
Gene Name (eCommerce)
envoplakin
Gene Name (Vector)
envoplakin
Gene Symbol
EVPL
HGNC ID
HGNC:3503
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
6168
ORF Size (bp)
6168 bp
Protein Name (eCommerce)
Envoplakin
RefSeq ID
NM_001988
RefSeq Synonyms
NM_001988, NM_001320747, BC143814, BC126105, BC126103,
Research Areas
Cytoskeleton
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Envoplakin is a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. The gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against Envoplakin [taken from NCBI Entrez Gene (Gene ID: 2125)].
UniGene ID
Hs.500635
UniProt ID (eCommerce)
Q92817

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.