human ETV6 shRNA silencing Adenovirus

Name
Ad-h-ETV6-shRNA

Cat No
shADV-208150

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human ETV6.

shADV-208150

Ad-h-ETV6-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ETV6 (ETS variant 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

ETS translocation variant 6; ets variant gene 6 (TEL oncogene); ETS-related protein Tel1; TEL; TEL/ABL; TEL1 oncogene; THC5; transcription factor ETV6

Description (eCommerce)

ETS translocation variant 6 (ETV6) functions as a transcriptional repressor. Gene knockout studies in mice suggest that ETV6 is required for hematopoiesis and maintenance of the developing vascular network. The ETV6 gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma [taken from NCBI Entrez Gene (Gene ID: 2120)].

Description (Vector)

ETV6 encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. ETV6 is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.

Gene ID

2120

Gene Name (eCommerce)

ETS variant 6

Gene Name (Vector)

ETS variant 6

Gene Symbol

ETV6

HGNC ID

HGNC:3495

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1359

ORF Size (bp)

1359 bp

Protein Name (eCommerce)

Transcription factor ETV6

RefSeq ID

NM_001987

RefSeq Synonyms

NM_001987, BC043399,

Research Areas

Cancer,FGF Signaling,Signal Transduction,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer

Research Areas (Faceted)

cancer,cell_biology,signal_transduction,transcription_translation

Species

human

Target Sentence

ETS translocation variant 6 (ETV6) functions as a transcriptional repressor. Gene knockout studies in mice suggest that ETV6 is required for hematopoiesis and maintenance of the developing vascular network. The ETV6 gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma [taken from NCBI Entrez Gene (Gene ID: 2120)].

UniGene ID

Hs.504765

UniProt ID (eCommerce)

P41212

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.