human ETV1 shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-208142
Availability:
5-8 weeks
Name:
Ad-h-ETV1-shRNA
This is an Adenovirus expressing shRNA for silencing of Human ETV1.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- ETV1
- Gene Name
- ETS variant 1
- Gene ID
- 2115
- Gene Synonyms
- ER81
- ORF Size
- 1434 bp
- RefSeq#
- NM_004956
- Gene Description
- ETV1 encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA(AT)-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. ETV1 is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Erwing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
- UniGene ID
- Hs.22634
- HGNC ID
- HGNC:3490
Related Products
Product | Cat No. |
---|---|
AAV-h-ETV1 | AAV-208142 |
AAV-m-ETV1 | AAV-258742 |
Ad-h-ETV1 | ADV-208142 |
Ad-m-ETV1 | ADV-258742 |
AAV-h-ETV1-shRNA | shAAV-208142 |
AAV-m-ETV1-shRNA | shAAV-258742 |
Ad-m-ETV1-shRNA | shADV-258742 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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