human EPAS1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human EPAS1.
shADV-207955
Ad-h-EPAS1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human EPAS1 (endothelial PAS domain protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
basic-helix-loop-helix-PAS protein MOP2; bHLHe73; class E basic helix-loop-helix protein 73; ECYT4; endothelial PAS domain-containing protein 1; EPAS-1; HIF-1-alpha-like factor; HIF-1alpha-like factor; HIF2A; HIF-2-alpha; HIF2-alpha; HLF; hypoxia-inducible factor 2 alpha; Hypoxia-inducible factor 2-alpha; member of PAS protein 2; MOP2; PAS domain-containing protein 2; PASD2
Description (eCommerce)
The gene EPAS1 encodes for the transcription factor endothelial PAS domain-containing protein 1, and is induced as oxygen levels fall. Commonly called hypoxia inducible factor 2A (HIF2a), this protein is involved in the induction of oxygen regulated genes, binding to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. An important cancer biomarker, HIF2a may also play a role in Tibetan high-altitude adaptation (Am J Hum Genet. 2015 Jul 2; 97(1): 54–66.) and mutations in the EPAS1 gene are associated with erythrocytosis familial type 4 [taken from NCBI Entrez Gene (Gene ID: 2034) and UniProtKB (Entry: Q99814)].
Description (Vector)
EPAS1 encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
Gene ID
2034
Gene Name (eCommerce)
endothelial PAS domain protein 1
Gene Name (Vector)
endothelial PAS domain protein 1
Gene Symbol
EPAS1
HGNC ID
HGNC:3374
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2613
ORF Size (bp)
2613 bp
Protein Name (eCommerce)
Endothelial PAS domain-containing protein 1
RefSeq ID
NM_001430
RefSeq Synonyms
NM_001430, BC051338,
Research Areas
Angiogenesis,Cancer,Cardiology,Cardiovascular,Gene Expression,Hypoxia,Kidney Cancer,Neurobiology,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,neurobiology,signal_transduction,transcription_translation,developmental_biology
Species
human
Target Sentence
The gene EPAS1 encodes for the transcription factor endothelial PAS domain-containing protein 1, and is induced as oxygen levels fall. Commonly called hypoxia inducible factor 2A (HIF2a), this protein is involved in the induction of oxygen regulated genes, binding to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. An important cancer biomarker, HIF2a may also play a role in Tibetan high-altitude adaptation (Am J Hum Genet. 2015 Jul 2; 97(1): 54–66.) and mutations in the EPAS1 gene are associated with erythrocytosis familial type 4 [taken from NCBI Entrez Gene (Gene ID: 2034) and UniProtKB (Entry: Q99814)].
UniGene ID
Hs.468410
UniProt ID (eCommerce)
Q99814
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.