human ENSA shRNA silencing Adenovirus

Name 
Ad-h-ENSA-shRNA
Cat No 
shADV-207940
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ENSA.

shADV-207940
Ad-h-ENSA-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ENSA (endosulfine alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ARPP-19e
Description (Vector)
ENSA belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.
Gene ID
2029
Gene Name (Vector)
endosulfine alpha
Gene Symbol
ENSA
HGNC ID
HGNC:3360
ORF Size (aa)
318
RefSeq ID
NM_004436
RefSeq Synonyms
NM_207168, NM_207047, NM_207046, NM_207045, NM_207044, NM_207043, NM_207042, NM_004436, BC069208, BC068544, BC004461, BC000436,
Species
human
UniGene ID
Hs.632456

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.