human ENAH shRNA silencing Adenovirus

Name 
Ad-h-ENAH-shRNA
Cat No 
shADV-207902
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ENAH.

shADV-207902
Ad-h-ENAH-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ENAH (enabled homolog (Drosophila)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ENA; enabled homolog; mammalian enabled variant 11a; mammalian enabled variant pan; MENA; NDPP1; protein enabled homolog
Description (eCommerce)
ENAH/MENA belongs to the Ena/vasodilator-stimulated phosphoprotein (VASP) family of proteins which play a role in regulating the actin cytoskeleton for the control of cell shape and movement. The Ena/VASP family of actin binding proteins includes ENAH/MENA which is the human homolog of drosophila Ena (enabled), VASP, and EVL (Ena/vasodilator-stimulated phosphoprotein-like protein). Ena/VASP proteins contain an EVH1 domain, a central proline-rich domain, and a terminal EVH2 domain. ENAH/MENA is not expressed in normal breast but has been detected and associated with breast lesions with a high risk of transformation and primary and metastatic breast cancer.
Gene ID
55740
Gene Name (eCommerce)
ENAH, actin regulator
Gene Name (Vector)
enabled homolog (Drosophila)
Gene Symbol
ENAH
HGNC ID
HGNC:18271
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1776
ORF Size (bp)
1776 bp
Protein Name (eCommerce)
Protein enabled homolog
RefSeq ID
NM_018212
RefSeq Synonyms
NM_018212, NM_001008493, BC095481, BC010414,
Research Areas
Axon Guidance,Cytoskeleton,Immunology,Neurobiology,Neurodevelopment,Synapse,T-cell Receptor Signaling,Transport
Research Areas (Faceted)
signal_transduction,neurobiology,cell_biology,immunology,neurobiology,developmental_biology,signal_transduction,immunology,cell_biology
Species
human
Target Sentence
ENAH/MENA belongs to the Ena/vasodilator-stimulated phosphoprotein (VASP) family of proteins which play a role in regulating the actin cytoskeleton for the control of cell shape and movement. The Ena/VASP family of actin binding proteins includes ENAH/MENA which is the human homolog of drosophila Ena (enabled), VASP, and EVL (Ena/vasodilator-stimulated phosphoprotein-like protein). Ena/VASP proteins contain an EVH1 domain, a central proline-rich domain, and a terminal EVH2 domain. ENAH/MENA is not expressed in normal breast but has been detected and associated with breast lesions with a high risk of transformation and primary and metastatic breast cancer.
UniGene ID
Hs.497893
UniProt ID (eCommerce)
Q8N8S7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.