human EIF3G shRNA silencing Adenovirus

Name 
Ad-h-EIF3G-shRNA
Cat No 
shADV-207751
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EIF3G.

shADV-207751
Ad-h-EIF3G-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EIF3G (eukaryotic translation initiation factor 3 subunit G). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
eIF3 p42; eIF3 p44; eIF-3 RNA-binding subunit; eIF-3-delta; eIF3-delta; eIF3g; EIF3-P42; eIF3-p44; EIF3S4; eukaryotic translation initiation factor 3 RNA-binding subunit; Eukaryotic translation initiation factor 3 subunit 4; eukaryotic translation initiation factor 3 subunit G; eukaryotic translation initiation factor 3 subunit p42; eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa
Description (eCommerce)
Eukaryotic initiation factor 3 subunit G (eIF3G) is one of at least 13 non-identical protein subunits of eukaryotic initiation factor 3 (eIF3). eIF3 is the largest eIF (~650 kDa) and functions to facilitate binding of the 40S ribosomal subunit to the 5’-end of cellular mRNAs near the cap structure (m7GpppN). eIF3G has been shown to directly interact with AIF (apoptosis inducing factor), a protein that plays a role in caspase-independent apoptosis. AIF is able to inhibit protein synthesis via its interaction with eIF3g.
Gene ID
8666
Gene Name (eCommerce)
eukaryotic translation initiation factor 3 subunit G
Gene Name (Vector)
eukaryotic translation initiation factor 3 subunit G
Gene Symbol
EIF3G
HGNC ID
HGNC:3274
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
963
ORF Size (bp)
963 bp
Protein Name (eCommerce)
Eukaryotic translation initiation factor 3 subunit G
RefSeq ID
NM_003755
RefSeq Synonyms
NM_003755, BC008469, BC000733,
Research Areas
Gene Expression,Metabolism/Metabolic Process,mRNA Binding,RNA Binding,RNA Transport,Translational Control
Research Areas (Faceted)
genetics,transcription_translation,metabolism,cell_biology
Species
human
Target Sentence
Eukaryotic initiation factor 3 subunit G (eIF3G) is one of at least 13 non-identical protein subunits of eukaryotic initiation factor 3 (eIF3). eIF3 is the largest eIF (~650 kDa) and functions to facilitate binding of the 40S ribosomal subunit to the 5’-end of cellular mRNAs near the cap structure (m7GpppN). eIF3G has been shown to directly interact with AIF (apoptosis inducing factor), a protein that plays a role in caspase-independent apoptosis. AIF is able to inhibit protein synthesis via its interaction with eIF3g.
UniGene ID
Hs.529059
UniProt ID (eCommerce)
O75821

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.